Isolation and Structure of Hematoside-Type Ganglioside from the Starfish Linckia laevigata
نویسندگان
چکیده
منابع مشابه
Isolation and structure of hematoside-type ganglioside from the starfish Linckia laevigata.
A hematoside-type ganglioside, LLG-1 (1), has been obtained from the polar lipid fraction of the chloroform/methanol extract of the starfish Linckia laevigata. The structure of the ganglioside has been determined on the basis of chemical and spectroscopic evidence as 1-O-[N-glycolyl-alpha-D-neuraminosyl-(2-->3)-beta-D-galactopyranosyl-(1-->4)-beta-D-glucopyranosyl]-ceramide. The ceramide moiety...
متن کاملChem. Pharm. Bull. 53(12) 1551—1554 (2005)
cosphingolipids from starfish, we have isolated cerebrosides, ceramide-lactosides, sulfatides, and gangliosides having some biological activities. As a continuation of our previous studies, we recently carried out the isolation and structure elucidation of a disialo-ganglioside molecular species, LLG-3, i.e., 8-O-Me-NeuAca2→11NeuGca2→3Galb1→ 4Glcb1→1ceramides, from the starfish Linckia laevigat...
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15 صفحه اولPhysiopathological function of hematoside (GM3 ganglioside)
Since I was involved in the molecular cloning of GM3 synthase (SAT-I), which is the primary enzyme for the biosynthesis of gangliosides in 1998, my research group has been concentrating on our efforts to explore the physiological and pathological implications of gangliosides especially for GM3. During the course of study, we demonstrated the molecular pathogenesis of type 2 diabetes and insulin...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2009
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.57.204